logo h2020

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 675879.

Doctoral Industrial School for Vaccine Design through Structural Mass Spectrometry
Call for 4 Early Stage Researcher Fellowships in "Doctoral Industrial School for Vaccine Design through Structural Mass Spectrometry"
INTRODUCTION

VADEMA (Doctoral Industrial School for Vaccine Design through Structural Mass Spectrometry) aims at delivering industry-oriented PhD training in the field of structural mass spectrometry applied to vaccinology. The four selected Early-Stage Researchers (ESRs) will experience an intersectoral training programme encompassing a 18-months internship in Glaxo Smith Kline Vaccines (GSKVACSRL), based in Siena, Italy, and 18-months internship at Department of Pharmacy, in University of Copenhagen (UCPH), DK. The students will be enrolled in the Graduate School of Health and Medical Sciences and affiliated to the graduate programme in pharmaceutical sciences, the Drug Research Academy PhD school at UCPH. All students will engage in training-by-research, and will participate in a series of scientific, technical and complementary skills training events.

RESEARCH PROJECT

VADEMA (Doctoral Industrial School for Vaccine Design through Structural Mass Spectrometry) is a European Industrial Doctorate (EID) funded by the Marie Skłodowska-Curie Actions of Horizon 2020, with the aim of training four young scientists in the structural mass spectrometry and vaccinology fields. The scope of the Project is to develop a Structural Mass Spectrometry platform, and exploit its application to compare conformation and dynamics of antigens in their native states (membrane) with their recombinant soluble forms (vaccines) and to get a better understanding of the humoral response raised against the two forms. The outcome of such studies will be the identification of antigen portions accessible to the host immune system and those epitopes that can be recognized in the native form of the antigens to design efficient vaccines.

It represents a good opportunity for students that are willing to grow both in basic science as well as in innovative and applicative experimental research.

Specifically, students will be involved in two work packages aimed at:

Development of a Structural Mass Spectrometry platform for vaccine design. The HDX-MS techniques will be used to study membrane-bound protein antigens in their native lipid environments and for epitope mapping with monoclonal and polyclonal antibodies.
Application of a Structural Mass Spectrometry platform to improve vaccine design. Each ESR will develop one aspect of the Structural Mass Spectrometry using one of the Bexsero® antigen as proof of concept. The same antigen will be kept by each ESR to be characterized in more detail and potentially improved by the application of the Structural Mass Spectrometry platform.

The 4 Early Stage Researchers (ESR)’ projects are in the following table; to apply to a specific project, click on the title and follow the instructions.


ESR1: Structural Mass Spectrometry to study membrane antigens of low abundance

First Host Institution: GSK

OPEN Expected start date:
01/07/2017
ESR2: Structural Mass Spectrometry to investigate the humoral response to vaccination

First Host Institution: UCPH

OPEN Expected start date:
01/07/2017
ESR3: Investigate the humoral response to vaccination through mass spectrometry

First Host Institution: GSK

OPEN Expected start date:
01/09/2017
ESR4: Structural mass spectrometry to study membrane antigens in their native state

First Host Institution: UCPH

OPEN Expected start date:
01/09/2017

Call deadline: February 28th 2017


TRAINING PROGRAMME

The training programme comprises:

  1. Research training activities, performed locally, leading to award of the PhD title.
  2. Scientific/technical training courses and activities performed locally and at the project level to train the ESRs in scientific topics, advanced technology and methodologies necessary for the project implementation.
  3. Transferable skills training to prepare the ESRs for an academic or industrial career will be provided through local and joint training courses.
  4. Scientific events, such as 3 annual project meetings and 1 mid-term meeting, where the fellows will be required to present their achievements and progress to a senior audience.

The PhD programme at the Faculty of Health and Medical Sciences, UCPH comprises:

An independent research project under supervision
Scientific articles and the PhD thesis on the grounds of the research project
PhD courses or other equivalent education corresponding to approx. 30 ECTS points
Experience with teaching or other types of dissemination related to the PhD project
Undergraduate teaching of students in pharmaceutical sciences
National and international congresses and scientific meetings
Stay at an external research institution, preferably abroad

The successful applicants will be requested to formally apply for enrolment as a PhD student at the Faculty of Health and Medical Sciences according to the rules stipulated in the Ministerial order on the PhD programme at the universities (PhD order) from the Ministry of Science, Innovation, and Higher Education, Denmark and the guidelines for the PhD programme at the Faculty of Health and Medical Sciences, UCPH and is expected to be affiliated to the graduate programme in pharmaceutical sciences, Drug Research Academy.


IMPLEMENTATION

ESR1 and ESR3 will be employed by GSK for the first 18 months of their fellowship, and by UCPH for the second period of the fellowship (months 19-36). ESR2 and ESR4 will be employed by UCPH for the first 18 months of their fellowship, and by GSK for the second period of the fellowship (months 19-36). All the fellows will be enrolled in the Graduate School of Health and Medical Sciences and affiliated to the graduate programme in pharmaceutical sciences, the Drug Research Academy at UCPH. The ESRs will be contractually employed according to Danish and Italian legislation and will be covered under the social security scheme of Denmark and Italy. They will monthly receive a Living Allowance, a Mobility Allowance and a Family Allowance (where applicable) compliant with the applicable EC Marie Skłodowska-Curie Actions – ITN general conditions (see the pdf document - page 49).

Salary and other terms and conditions of appointment as to the employment at UCPH are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organizations. Minimum monthly salary is DKK 25,579 (taxable) + pension contribution + mobility allowance and family allowance (where applicable).


ELIGIBILITY RULES

At the time of recruitment, i.e., July 1st 2017 and September 1st 2017 applicants must fulfil the following rules:

Experience:

  1. applicants must be in possession of the degree (usually the Master Degree) which would formally entitle them to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the researcher will be recruited.
  2. applicants must be ESRs, i.e. must be in the first four years (full-time equivalent research experience) of their research careers and have not yet been awarded a doctoral degree.
  3. applicants will be preferred that have experience within specifically.


Mobility:

ESR1 and ESR3: applicants can be of any nationality but, at the time of recruitment, may not have resided or carried out their main activity in Italy for more than 12 months in the 3 years immediately prior to the enrolment. Short stays such as holidays are not taken into account.

ESR2 and ESR4: applicants can be of any nationality but, at the time of selection, may not have resided or carried out their main activity in Denmark for more than 12 months in the 3 years immediately prior to the enrolment. Short stays such as holidays are not taken into account.


Other requirements:

  1. ESR1: Basic knowledge: protein chemistry, protein structure and analytical chemistry Specific skills: molecular biology, liquid chromatography and mass spectrometry
    ESR2: Basic knowledge: protein chemistry, protein structure and analytical chemistry Specific skills: liquid chromatography and mass spectrometry
    ESR3: Basic knowledge: protein chemistry, protein structure and analytical chemistry Specific skills: liquid chromatography and mass spectrometry
    ESR4: Basic knowledge: protein chemistry, protein structure and analytical chemistry Specific skills: liquid chromatography and mass spectrometry

  2. The CV must be without gaps, in order to easily check the mobility and experience rules. CVs that either do not clearly show the applicant’s past experience, or have unexplained gaps, will be considered ineligible.

HOW TO APPLY

To apply to a specific project, click on the title in the table above, and follow the instructions.

For more information and details on the application procedure, please contact info@vadema.eu



pdf Download all the information


Last update: January 11, 2017


Copyright © 2016 VADEMA - All Rights Reserved - Powered by ALTA